JPH0333155B2 - - Google Patents

Info

Publication number
JPH0333155B2
JPH0333155B2 JP58233404A JP23340483A JPH0333155B2 JP H0333155 B2 JPH0333155 B2 JP H0333155B2 JP 58233404 A JP58233404 A JP 58233404A JP 23340483 A JP23340483 A JP 23340483A JP H0333155 B2 JPH0333155 B2 JP H0333155B2
Authority
JP
Japan
Prior art keywords
hydrogen
formula
ethoxy
hydroxyethoxy
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58233404A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60155171A (ja
Inventor
Masao Morita
Haruyoshi Sugimoto
Masaaki Mizuno
Mikiaki Tanaka
Fumyoshi Urano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Wako Pure Chemical Corp
Original Assignee
Wako Pure Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wako Pure Chemical Industries Ltd filed Critical Wako Pure Chemical Industries Ltd
Priority to JP58233404A priority Critical patent/JPS60155171A/ja
Priority to CA000469359A priority patent/CA1227209A/en
Priority to AT84114930T priority patent/ATE41772T1/de
Priority to US06/679,346 priority patent/US4574156A/en
Priority to EP84114930A priority patent/EP0144991B1/en
Priority to DE8484114930T priority patent/DE3477488D1/de
Publication of JPS60155171A publication Critical patent/JPS60155171A/ja
Publication of JPH0333155B2 publication Critical patent/JPH0333155B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP58233404A 1983-12-10 1983-12-10 ポリメトキシベンジルピペラジン誘導体 Granted JPS60155171A (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP58233404A JPS60155171A (ja) 1983-12-10 1983-12-10 ポリメトキシベンジルピペラジン誘導体
CA000469359A CA1227209A (en) 1983-12-10 1984-12-05 Polymethoxybenzyl piperazine derivatives
AT84114930T ATE41772T1 (de) 1983-12-10 1984-12-07 Polymethoxybenzyl-piperazin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende pharmazeutische zusammensetzungen.
US06/679,346 US4574156A (en) 1983-12-10 1984-12-07 Polymethoxybenzyl piperazine derivatives effective for improving blood circulation system
EP84114930A EP0144991B1 (en) 1983-12-10 1984-12-07 Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives
DE8484114930T DE3477488D1 (en) 1983-12-10 1984-12-07 Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58233404A JPS60155171A (ja) 1983-12-10 1983-12-10 ポリメトキシベンジルピペラジン誘導体

Publications (2)

Publication Number Publication Date
JPS60155171A JPS60155171A (ja) 1985-08-15
JPH0333155B2 true JPH0333155B2 (en]) 1991-05-16

Family

ID=16954540

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58233404A Granted JPS60155171A (ja) 1983-12-10 1983-12-10 ポリメトキシベンジルピペラジン誘導体

Country Status (6)

Country Link
US (1) US4574156A (en])
EP (1) EP0144991B1 (en])
JP (1) JPS60155171A (en])
AT (1) ATE41772T1 (en])
CA (1) CA1227209A (en])
DE (1) DE3477488D1 (en])

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8705574D0 (en) * 1987-03-10 1987-04-15 Ici Plc Preparation of thiazepine compound
US5098755A (en) * 1990-11-21 1992-03-24 Tanquary Albert C Textured thermoplastic elastomeric film, articles comprising same, and method of making such textured thermoplastic elastomeric film and articles
AU646926B2 (en) * 1991-03-20 1994-03-10 Duphar International Research B.V. Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
WO1995004050A1 (en) * 1993-07-28 1995-02-09 Santen Pharmaceutical Co., Ltd. Novel 1,4-di(phenylalkyl)piperazine derivative
MX2019007838A (es) 2016-12-27 2019-09-09 Basf Se Articulo de espuma de poliuretano y metodo para formarlo.
CN111093662B (zh) 2017-06-20 2023-10-03 安布里亚制药公司 用于提高心脏代谢效率的组合物和方法
EP4497474A3 (en) * 2018-10-17 2025-04-23 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US12076318B2 (en) 2020-12-10 2024-09-03 Imbria Pharmaceuticals, Inc. Methods of treating heart failure with hibernating myocardium using modified forms of trimetazidine
US11793807B2 (en) 2020-12-10 2023-10-24 Imbria Pharmaceuticals, Inc. Methods of treating heart failure with preserved ejection fraction using modified forms of trimetazidine
US11969422B2 (en) 2020-12-10 2024-04-30 Imbria Pharmaceuticals, Inc. Methods of treating heart failure with reduced ejection fraction using modified forms of trimetazidine
US11730733B2 (en) 2020-12-10 2023-08-22 Imbria Pharmaceuticals, Inc. Methods of treating non-obstructive hypertrophic cardiomyopathy using modified forms of trimetazidine
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE523903A (en]) *
US2995553A (en) * 1960-01-25 1961-08-08 Abbott Lab Substituted piperazines
US4100285A (en) * 1976-04-09 1978-07-11 Nippon Shinyaku Co., Ltd. N-substituted trialkoxybenzyl piperazine derivatives
JPS6154474A (ja) * 1984-08-25 1986-03-18 Fuji Electric Co Ltd 電力量計の試験装置

Also Published As

Publication number Publication date
DE3477488D1 (en) 1989-05-03
EP0144991B1 (en) 1989-03-29
ATE41772T1 (de) 1989-04-15
CA1227209A (en) 1987-09-22
JPS60155171A (ja) 1985-08-15
EP0144991A3 (en) 1985-07-17
EP0144991A2 (en) 1985-06-19
US4574156A (en) 1986-03-04

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